Summary Of Changes In CPT 2025
Overview of the 2025 CPT Code Updates
The recent 2025 CPT update introduces 420 changes across the code set, including 270 new codes, 112 deletions, and 38 revisions.
| Total CPT codes in 2025 | Total Changes | Added codes | Deleted codes | Revised codes |
|---|---|---|---|---|
| 11321 | 420 | 270 | 112 | 38 |
Key Highlights of the 2025 Updates
The largest share of new codes (37%) are related to Proprietary Laboratory Analyses (PLA), particularly focusing on advanced genetic testing. This emphasizes the growing role of personalized medicine in healthcare.
Major Sections with Updates:
- Surgery
- Evaluation and Management (E&M)
- Radiology, Pathology, Laboratory, and Medicine
- Category III Codes
- Proprietary Laboratory Analyses (PLA)
The Impact of New Codes on Healthcare Economics
New CPT codes do not automatically ensure reimbursement but create opportunities for providers to justify payer coverage based on clinical value and cost-effectiveness. These updates influence pricing strategies and reimbursement frameworks for innovative technologies and services.
Quick Key Updates
| 2025 CPT codes | ||||
|---|---|---|---|---|
| Code Series | Section | New | Revised | Deleted |
| 00100-01999 | Anesthesia | 0 | 0 | 0 |
| 10004-69990 | Surgery | 33 | 5 | 13 |
| 70010-79999 | Radiology procedures | 6 | 0 | 0 |
| 80047-89398 | Pathology and laboratory procedures | 14 | 5 | 6 |
| 90281-99607 | Medicine services and procedures | 18 | 22 | 69 |
| 99202-99499 | E/M services | 17 | 0 | 3 |
| 0001F-9007F | Category II codes | 0 | 0 | 0 |
| 0042T-0639T | Category III codes | 81 | 2 | 13 |
| 0001U-0222U | PLA Codes | 101 | 4 | 8 |
| Total | 270 | 38 | 112 | |
Key CPT Codes to Watch in 2025
The section within the CPT code set on general surgery has been revised in order to incorporate new surgical approaches and techniques, especially in the areas pertaining to skin grafting and the removal of tumours in the abdomen. These changes are a reflection of the never-ending evolution of surgical practices which are advantageous to the recovery and outcome of the patient.
| 2025 Surgical CPT Codes (10004 - 69990) | ||||
|---|---|---|---|---|
| Code Series | Section | New | Revised | Deleted |
| 10004-10021 | General surgical procedures | 0 | 0 | 0 |
| 10030-19499 | Integumentary system | 8 | 0 | 2 |
| 20100-29999 | Musculoskeletal system | 1 | 1 | 0 |
| 30000-32999 | Respiratory system | 0 | 0 | 0 |
| 33016-37799 | Cardiovascular system | 0 | 1 | 3 |
| 38100-38999 | Hemic and lymphatic systems | 4 | 0 | 0 |
| 39000-39599 | Mediastinum and diaphragm | 0 | 0 | 0 |
| 40490-49999 | Digestive system | 5 | 0 | 4 |
| 50010-53899 | Urinary system | 3 | 1 | 2 |
| 54000-55899 | Male genital system | 2 | 0 | 1 |
| 55920-55920 | Reproductive system procedures | 0 | 0 | 0 |
| 55970-55980 | Intersex surgery | 0 | 0 | 0 |
| 56405-58999 | Female genital system | 0 | 1 | 1 |
| 59000-59899 | Maternity care and delivery | 0 | 0 | 0 |
| 60000-60699 | Endocrine system | 2 | 0 | 0 |
| 61000-64999 | Nervous system | 7 | 0 | 0 |
| 55091-68899 | Eye and ocular adnexa | 1 | 1 | 0 |
| 69000-69979 | Auditory system | 0 | 0 | 0 |
| 69990-69990 | Operating microscope procedures | 0 | 0 | 0 |
| Total | 33 | 5 | 13 | |
Key Updates in the 2025 CPT Code Set
The 2025 CPT code set introduces significant changes, and that impacts several specialties, including cardiology, general surgery, and radiology. In addition to it, there are updates across vaccines/laboratory codes, telemedicine, remote patient monitoring (RPM), and more.
Specialty-Specific Highlights
-
Cardiology:
New Category III codes focus on advancements in electrocardiogram and cardiac contractility modulation-defibrillator systems.
-
General Surgery:
Codes 15011–15018 reflect innovative surgical techniques for skin grafting in wound care and recovery. Additional codes (49186–49190) address advancements in tumor removal procedures within the abdominal region.
-
Radiology:
New CPT codes include procedures such as MRI-monitored transurethral ultrasound ablation of the prostate, transcranial Doppler, percutaneous radiofrequency ablation of the thyroid, fascial plane blocks, and MRI safety assessments. Notably, the update elevates MRI-guided high-intensity focused ultrasound from Category III to Category I.
-
Vaccines and Labs:
Changes include updates to vaccination codes, proprietary laboratory analysis, and genetic testing. A new genetic counseling code (96041) replaces 96040, now allowing reporting based on total time spent on the encounter date, with the removal of "face-to-face" from the description.
Critical Codes to Watch
Remote Patient Monitoring (RPM)
The section within the CPT code set on general surgery has been revised in order to incorporate new surgical approaches and techniques, especially in the areas pertaining to skin grafting and the removal of tumours in the abdomen. These changes are a reflection of the never-ending evolution of surgical practices which are advantageous to the recovery and outcome of the patient.
CPT 98975: Expanded to include digital therapeutic interventions.
CPT 98976–98978: Updated to cover devices enabling data access or transmission for RPM.
CPT 98980: Adjusted to require 11–20 minutes of provider time, down from 20+ minutes.
Six new codes address RPM for shorter durations, covering the first 2 to 15 days (99XX4–99XX5, 98XX4–98XX7). These updates support RPM practices in the growing hospital-at-home movement.
Telemedicine
Telemedicine updates include:
-
17 new codes for audio-video visits:
New patients: 98000–98003
Established patients: 98004–98007.
-
Replacement of telephone-only codes (99441–99443) with new audio-only telemedicine codes:
New patients: 98008–98011.
Established patients: 98012–98015.
-
New virtual check-in code (98016) replaces HCPCS code G2012.
These changes enhance telemedicine’s role in expanding access and boosting revenue post-pandemic.
Augmented/Artificial Intelligence (AI)
Seven new Category III codes highlight AI’s growing impact in healthcare:
AI-powered analysis of medical chest imaging (0877T–0880T).
AI-powered analysis of medical chest imaging (0877T–0880T).
AI-guided prostate biopsies (0898T).
Preparation for 2025 CPT Updates
To adapt to these changes, providers and billers should:
Acquire updated CPT manuals.
Update electronic health record (EHR) systems.
Communicate with payers regarding coverage policies.
Train staff on new coding requirements.
Ensure providers are familiar with specialty-relevant updates.